Freeline Therapeutics Holdings plc
Initiate dose escalation in Part 1 of the MARVEL-1 Phase 1/2 study
Delivered by the deadline
AI-assessed · human review in progress Found and assessed by AI from the cited sources. Shown with its evidence; it is not counted in any Kept Score until confirmed.
- Announced
- 8 Feb 2021
- Due
- 31 Dec 2021
- Delivered
- Q2 2021
- Deadline
- Met
- Late
- Not met
- Today
What the company said
“planned initiation of ... dose escalation in Part 1 of the ongoing MARVEL-1 Phase 1/2 study in Fabry disease later this year.”
What we found
Evidence strength A What the grades mean
The company initiated dose escalation in the MARVEL-1 trial by dosing the second patient in the second quarter of 2021, which occurred before the end of the year.
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A Freeline Therapeutics Holdings plc 20-F filed 2022-03-31
“We dosed our first patient in the Phase 1/2 MARVEL-1 clinical trial in the third quarter of 2019 and our second patient in the second quarter of 2021.” ✓ confirmed on the page
Checked 25 Oct 2026.
Commitment DNA
The structured record of this commitment. Fields the company did not state are left blank rather than guessed.
- Event type
- Project other
- Indicative materiality
- Low rules
- Action
- Initiate
- Deliverable
- MARVEL-1 Phase 1/2 study dose escalation
- Language
- Expected (“expects”, “plans”)
- In the company’s control
- Medium
- Specificity
- High
- Depends on
- Regulatory
How this entry was checked
- Commitment recordedThe company's words were matched word for word against the filing.
- First checkAn AI model, Gemini (Google), read the company's later filings and recorded the outcome with a quoted passage.
- Second check: disagreesClaude (Anthropic) re-read the evidence blind and read it as “no_evidence”.
- Tie-breakA stronger model read the evidence and both earlier answers, without knowing which was recorded, and agrees with the second check.
Not yet confirmed. Shown on the record, but it will not count in any score until it is confirmed. How verification works
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